Kidney Question?

Can someone please explain the use of 'clearance' methods to quantify kidney excretory fuctions? - Inulin and Creatinine clearance to estimate GFR and PAH to estimate renal plasma flow?
Thank you in credit. any clinical and laboratory proceduredesigned to evaluate various aspectsof renal (kidney) dimensions and efficiency and to aid contained by the diagnosis of kidney disorders. Such tests can be divided into several category, which include (1) clearance tests that contribute an estimate of the filtration rate of the glomeruli, the principal filtering structures of the kidneys (see inulin clearance), and overall renal blood flow (see phenolsulfonphthalein test); (2) concentration and dilution experiment, whereby the specific gravity of urine is determined at regular timeintervals following water restriction or ample water intake, to method the capacity of the kidneys to conserve hose down; (3) visual and physical nouns of the urine, which usually includes the recording of its physical characteristics such as colour, total volume, and specific gravity, as powerfully as checking for the abnormal presence of pus, hyaline cast (precipitation of pure protein from the kidney tubules), and red and white blood cells; proteinuria, thepresence of protein contained by the urine, is often the first nonstandard finding indicative of kidney disease; (4) determination of the concentration of various substances within the urine, notably glucose, amino acids, phosphate, sodium, and potassium, to support detect possible impairment of the specific kidney mechanisms in general involved with their reabsorption.
In accessory to clinical and laboratory tests, the use of X-rays and radioisotopes is also expensive in the diagnosis of kidney disorders (see urography).